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Article

A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2015

Jusko Monika, Potempa Jan, Mizgalska Danuta, Bielecka Ewa, Ksiazek Miroslaw, Riesbeck Kristian, Garred Peter, Eick Sigrun, Blom Anna M

Abstract excerpt

Recent reports focusing on virulence factors of periodontal pathogens implicated proteinases as major determinants of remarkable pathogenicity of these species, with special emphasis on their capacity to modulate complement activity. In particular, bacteria-mediated cleavage of C5 and subsequent release of C5a seems to be an important phenomenon in the manipulation of the local inflammatory response in...

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Source

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Identifiers

PMID: 26209620
DOI: 10.4049/jimmunol.1402892
PMCID: PMC4546851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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