Article
Limited Variation in BK Virus T-Cell Epitopes Revealed by Next-Generation Sequencing.
Journal of clinical microbiology - 1 Oct 2015
Sahoo Malaya K, Tan Susanna K, Chen Sharon F, Kapusinszky Beatrix, Concepcion Katherine R, Kjelson Lynn, Mallempati Kalyan, Farina Heidi M, Fernández-Viña Marcelo, Tyan Dolly, Grimm Paul C, Anderson Matthew W, Concepcion Waldo, Pinsky Benjamin A
Abstract excerpt
BK virus (BKV) infection causing end-organ disease remains a formidable challenge to the hematopoietic cell transplant (HCT) and kidney transplant fields. As BKV-specific treatments are limited, immunologic-based therapies may be a promising and novel therapeutic option for transplant recipients with persistent BKV infection. Here, we describe a whole-genome, deep-sequencing methodology and bioinformatics...
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