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Article

Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement.

PloS one - 1 Jan 2015

Williams Frances M, Kalson Nicholas S, Fabiane Stella M, Mann Derek A, Deehan David J

Abstract excerpt

OBJECTIVE: Joint stiffness is a common, debilitating, age-related symptom, which may be seen after total joint replacement (TJR). Stiffness also occurs in fibrotic conditions such as shoulder capsulitis and Dupuytren's contracture. We speculated that the two traits (TJR and fibrotic disease) are linked pathogenically. METHODS: Using the TwinsUK NIHR BRC BioResource we tested the hypotheses that 1) joint (hip and...

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Share to Arthroplasty, Replacement, Hip
Share to Arthroplasty, Replacement, Knee

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Osteoarthritis, Hip

Share to Osteoarthritis, Knee

Source

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Identifiers

PMID: 26197488
DOI: 10.1371/journal.pone.0133629
PMCID: PMC4509645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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