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Article

Knockout silkworms reveal a dispensable role for juvenile hormones in holometabolous life cycle.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015

Daimon Takaaki, Uchibori Miwa, Nakao Hajime, Sezutsu Hideki, Shinoda Tetsuro

Abstract excerpt

Insect juvenile hormones (JHs) prevent precocious metamorphosis and allow larvae to undergo multiple rounds of status quo molts. However, the roles of JHs during the embryonic and very early larval stages have not been fully understood. We generated and characterized knockout silkworms (Bombyx mori) with null mutations in JH biosynthesis or JH receptor genes using genome-editing tools. We found that embryonic...

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Identifiers

PMID: 26195792
DOI: 10.1073/pnas.1506645112
PMCID: PMC4534237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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