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Article

The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, Bombyx mori.

The Journal of biological chemistry - 14 Jul 2017

Zeng Baosheng, Huang Yuping, Xu Jun, Shiotsuki Takahiro, Bai Hua, Palli Subba Reddy, Huang Yongping, Tan Anjiang

Abstract excerpt

Forkhead box O (FOXO) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many organisms, including lifespan in insects. However, how FOXO interacts with hormone signaling to modulate insect growth and development is largely unknown. Here, using the transgene-based CRISPR/Cas9 system, we generated and characterized mutants of the...

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Identifiers

PMID: 28490635
DOI: 10.1074/jbc.M117.777797
PMCID: PMC5512063

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