Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.

doi:10.1038/ng.3358

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Article

Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.

Nature genetics - 1 Sept 2015

Jiang Lu, Gu Zhao-Hui, Yan Zi-Xun, Zhao Xia, Xie Yin-Yin, Zhang Zi-Guan, Pan Chun-Ming, Hu Yuan, Cai Chang-Ping, Dong Ying, Huang Jin-Yan, Wang Li, Shen Yang, Meng Guoyu, Zhou Jian-Feng, Hu Jian-Da, Wang Jin-Fen, Liu Yuan-Hua, Yang Lin-Hua, Zhang Feng, Wang Jian-Min, Wang Zhao, Peng Zhi-Gang, Chen Fang-Yuan, Sun Zi-Min, Ding Hao, Shi Ju-Mei, Hou Jian, Yan Jin-Song, Shi Jing-Yi, Xu Lan, Li Yang, Lu Jing, Zheng Zhong, Xue Wen, Zhao Wei-Li, Chen Zhu, Chen Sai-Juan

Abstract excerpt

Natural killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56(+) and cytoCD3(+) lymphocytes with aggressive clinical course, which is prevalent in Asian and South American populations. The molecular pathogenesis of NKTCL has largely remained elusive. We identified somatic gene mutations in 25 people with NKTCL by whole-exome sequencing and confirmed them in an extended validation group of 80 people...

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Identifiers

PMID: 26192917
DOI: 10.1038/ng.3358

Genes

ASXL3
MGA
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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