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Article

The Influence of Hepatitis C Virus Genetic Region on Phylogenetic Clustering Analysis.

PloS one - 1 Jan 2015

Lamoury François M J, Jacka Brendan, Bartlett Sofia, Bull Rowena A, Wong Arthur, Amin Janaki, Schinkel Janke, Poon Art F, Matthews Gail V, Grebely Jason, Dore Gregory J, Applegate Tanya L

Abstract excerpt

Sequencing is important for understanding the molecular epidemiology and viral evolution of hepatitis C virus (HCV) infection. To date, there is little standardisation among sequencing protocols, in-part due to the high genetic diversity that is observed within HCV. This study aimed to develop a novel, practical sequencing protocol that covered both conserved and variable regions of the viral genome and assess...

Topics

Cluster Analysis
Evolution, Molecular
Genotype
Hepacivirus
Humans
Phylogeny
RNA, Viral
Sequence Analysis, RNA

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26192190
DOI: 10.1371/journal.pone.0131437
PMCID: PMC4507989

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