Article
Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients.
Endocrine-related cancer - 1 Oct 2015
Rostomyan Liliya, Daly Adrian F, Petrossians Patrick, Nachev Emil, Lila Anurag R, Lecoq Anne-Lise, Lecumberri Beatriz, Trivellin Giampaolo, Salvatori Roberto, Moraitis Andreas G, Holdaway Ian, Kranenburg-van Klaveren Dianne J, Chiara Zatelli Maria, Palacios Nuria, Nozieres Cecile, Zacharin Margaret, Ebeling Tapani, Ojaniemi Marja, Rozhinskaya Liudmila, Verrua Elisa, Jaffrain-Rea Marie-Lise, Filipponi Silvia, Gusakova Daria, Pronin Vyacheslav, Bertherat Jerome, Belaya Zhanna, Ilovayskaya Irena, Sahnoun-Fathallah Mona, Sievers Caroline, Stalla Gunter K, Castermans Emilie, Caberg Jean-Hubert, Sorkina Ekaterina, Auriemma Renata Simona, Mittal Sachin, Kareva Maria, Lysy Philippe A, Emy Philippe, De Menis Ernesto, Choong Catherine S, Mantovani Giovanna, Bours Vincent, De Herder Wouter, Brue Thierry, Barlier Anne, Neggers Sebastian J C M M, Zacharieva Sabina, Chanson Philippe, Shah Nalini Samir, Stratakis Constantine A, Naves Luciana A, Beckers Albert
Abstract excerpt
Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients (163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height >2 s.d. above country normal...
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