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Article

Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies.

Drug design, development and therapy - 1 Jan 2015

Chiorean Elena Gabriela, Coveler Andrew L

Abstract excerpt

Pancreatic cancer is the fourth leading cause of cancer death in the US and is expected to become the second leading cause of cancer-related deaths in the next decade. Despite 5-fluorouracil/leucovorin with irinotecan and oxaliplatin (FOLFIRINOX) and gemcitabine/nab-paclitaxel significantly improving outcomes for metastatic cancer, refractory disease still poses significant challenges. Difficulties with early...

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Source

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Identifiers

PMID: 26185420
DOI: 10.2147/DDDT.S60328
PMCID: PMC4500614

Genes

KRAS
CCR2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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