Article
Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1.
JAMA oncology - 1 Dec 2015
Howitt Brooke E, Shukla Sachet A, Sholl Lynette M, Ritterhouse Lauren L, Watkins Jaclyn C, Rodig Scott, Stover Elizabeth, Strickland Kyle C, D'Andrea Alan D, Wu Catherine J, Matulonis Ursula A, Konstantinopoulos Panagiotis A
Abstract excerpt
IMPORTANCE: Immune checkpoint inhibitor therapy has shown benefit in various cancers, but their potential in endometrial cancer (EC) is unknown. OBSERVATIONS: Prediction of neoantigen load was performed using sequencing data from the Cancer Genome Atlas data set. Evaluation of tumor-infiltrating lymphocytes (TILs) and PD-1 and PD-L1 expression was performed in 63 patients with EC referred to our institution. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.