Article
HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition.
Science translational medicine - 15 Jul 2015
Prentice Heather A, Tomaras Georgia D, Geraghty Daniel E, Apps Richard, Fong Youyi, Ehrenberg Philip K, Rolland Morgane, Kijak Gustavo H, Krebs Shelly J, Nelson Wyatt, DeCamp Allan, Shen Xiaoying, Yates Nicole L, Zolla-Pazner Susan, Nitayaphan Sorachai, Rerks-Ngarm Supachai, Kaewkungwal Jaranit, Pitisuttithum Punnee, Ferrari Guido, McElrath M Juliana, Montefiori David C, Bailer Robert T, Koup Richard A, O'Connell Robert J, Robb Merlin L, Michael Nelson L, Gilbert Peter B, Kim Jerome H, Thomas Rasmi
Abstract excerpt
In the RV144 vaccine trial, two antibody responses were found to correlate with HIV-1 acquisition. Because human leukocyte antigen (HLA) class II-restricted CD4(+) T cells are involved in antibody production, we tested whether HLA class II genotypes affected HIV-1-specific antibody levels and HIV-1 acquisition in 760 individuals. Indeed, antibody responses correlated with acquisition only in the presence of...
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