Article
A multicenter validation of recombinant β3 integrin-coupled beads to detect human platelet antigen-1 alloantibodies in 498 cases of fetomaternal alloimmune thrombocytopenia.
Transfusion - 1 Nov 2015
Chong Winnie, Turro Ernest, Metcalfe Paul, Yusuf Rizwan, Mérieux Yves, Rigal Dominique, Porcelijn Leendert, Huiskes Elly, Lucas Geoff, Bendukidze Nina, Green Ann, Fontão-Wendel Rita, Husebekk Anne, Dixey Jonathan, Guest Alan, Mushens Rosey, Ouwehand Willem H, Navarrete Cristina V
Abstract excerpt
BACKGROUND: Fetomaternal alloimmune thrombocytopenia (FMAIT) is caused by human platelet (PLT) antigen (HPA) incompatibility. Beads coupled with recombinant β3 integrins, displaying the biallelic HPA-1 epitopes (rHPA-1), have been shown to detect HPA-1a alloantibodies implicated in FMAIT. This report describes a multicenter validation of the beads using the results of well-characterized samples to define the...
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