Article
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.
Oncotarget - 22 Sept 2015
Lenos Kristiaan, Goos Jeroen A C M, Vuist Ilona M, den Uil Sjoerd H, Delis-van Diemen Pien M, Belt Eric J Th, Stockmann Hein B A C, Bril Herman, de Wit Meike, Carvalho Beatriz, Giblett Susan, Pritchard Catrin A, Meijer Gerrit A, van Kooyk Yvette, Fijneman Remond J A, van Vliet Sandra J
Abstract excerpt
Colorectal cancer (CRC) is the third most prevalent cancer type worldwide with a mortality rate of approximately 50%. Elevated cell-surface expression of truncated carbohydrate structures such as Tn antigen (GalNAcα-Ser/Thr) is frequently observed during tumor progression. We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells,...
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