Article
LCN2 Promoter Methylation Status as Novel Predictive Marker for Microvessel Density and Aggressive Tumor Phenotype in Breast Cancer Patients.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Meka Phanni bhushann, Jarjapu Sarika, Nanchari Santhoshi Rani, Vishwakarma Sandeep Kumar, Edathara Prajitha Mohandas, Gorre Manjula, Cingeetham Anuradha, Vuree Sugunakar, Annamaneni Sandhya, Dunna Nageswara Rao, Mukta Srinivasulu, B Triveni, Satti Vishnupriya
Abstract excerpt
LCN2 (Lipocalin 2) is a 25 KD secreted acute phase protein, reported to be a novel regulator of angiogenesis in breast cancer. Up regulation of LCN2 had been observed in multiple cancers including breast cancer, pancreatic cancer and ovarian cancer. However, the role of LCN2 promoter methylation in the formation of microvessels is poorly understood. The aim of this study was to analyze the association of LCN 2...
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