Article
IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system.
Science (New York, N.Y.) - 10 Jul 2015
Spitzer Matthew H, Gherardini Pier Federico, Fragiadakis Gabriela K, Bhattacharya Nupur, Yuan Robert T, Hotson Andrew N, Finck Rachel, Carmi Yaron, Zunder Eli R, Fantl Wendy J, Bendall Sean C, Engleman Edgar G, Nolan Garry P
Abstract excerpt
Immune cells function in an interacting hierarchy that coordinates the activities of various cell types according to genetic and environmental contexts. We developed graphical approaches to construct an extensible immune reference map from mass cytometry data of cells from different organs, incorporating landmark cell populations as flags on the map to compare cells from distinct samples. The maps recapitulated...
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