Article
Does maternal VDR FokI single nucleotide polymorphism have an effect on lead levels of placenta, maternal and cord bloods?
Placenta - 1 Aug 2015
Kaya-Akyüzlü Dilek, Kayaaltı Zeliha, Söylemez Esma, Koca Deniz, Söylemezoğlu Tülin
Abstract excerpt
INTRODUCTION: Individual susceptibility due to genetic variations appears to be an important factor in lead toxicity. As lead, ubiquitous atmospheric pollutant, behaves very similarly to calcium, gene polymorphisms in proteins involved in calcium homeostasis can affect lead toxicokinetics. Vitamin D receptor (VDR), a DNA-binding transcription factor, activates genes that encode proteins involved in calcium...
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