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Article

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.

The Journal of biological chemistry - 21 Aug 2015

Kern Gunther, Palmer Tiffany, Ehmann David E, Shapiro Adam B, Andrews Beth, Basarab Gregory S, Doig Peter, Fan Jun, Gao Ning, Mills Scott D, Mueller John, Sriram Shubha, Thresher Jason, Walkup Grant K

Abstract excerpt

We characterized the inhibition of Neisseria gonorrhoeae type II topoisomerases gyrase and topoisomerase IV by AZD0914 (AZD0914 will be henceforth known as ETX0914 (Entasis Therapeutics)), a novel spiropyrimidinetrione antibacterial compound that is currently in clinical trials for treatment of drug-resistant gonorrhea. AZD0914 has potent bactericidal activity against N. gonorrhoeae, including multidrug-resistant...

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Identifiers

PMID: 26149691
DOI: 10.1074/jbc.M115.663534
PMCID: PMC4543657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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