Article
Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells.
Molecular cancer - 7 Jul 2015
De Amicis Francesca, Aquila Saveria, Morelli Catia, Guido Carmela, Santoro Marta, Perrotta Ida, Mauro Loredana, Giordano Francesca, Nigro Alessandra, Andò Sebastiano, Panno Maria L
Abstract excerpt
BACKGROUND: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, has shown antitumoral effects in a variety of cell types. In this study, it has been addressed how Bergapten in breast cancer cells induces autophagic process. RESULTS: In MCF7 and ZR-75 breast cancer cells Bergapten exhibited anti-survival response by inducing the autophagic process increasing Beclin1,...
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