Article
MAOA expression predicts vulnerability for alcohol use.
Molecular psychiatry - 1 Apr 2016
Cervera-Juanes R, Wilhem L J, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones S R, Grant K A, Ferguson B
Abstract excerpt
The role of the monoamines dopamine (DA) and serotonin (5HT) and the monoamine-metabolizing enzyme monoamine oxidase A (MAOA) have been repeatedly implicated in studies of alcohol use and dependence. Genetic investigations of MAOA have yielded conflicting associations between a common polymorphism (MAOA-LPR) and risk for alcohol abuse. The present study provides direct comparison of tissue-specific MAOA...
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