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Article

A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface

6 Jul 2015

Abstract excerpt

Norovirus (NoV) causes epidemic acute gastroenteritis in humans, whereby histo-blood group antigens (HBGAs) play an important role in host susceptibility. Each of the two major genogroups (GI and GII) of human NoVs recognizes a unique set of HBGAs through a distinct binding interface that is conserved within a genogroup, indicating a distinct evolutionary path for each genogroup. Here, we characterize a Lewis a...

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PMID: 26147716
DOI: 10.1371/journal.ppat.1005025

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