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Article

Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments.

PloS one - 1 Jan 2015

Qi Yuan, Liu Xiuping, Liu Chang-Gong, Wang Bailing, Hess Kenneth R, Symmans W Fraser, Shi Weiwei, Pusztai Lajos

Abstract excerpt

Nucleotide alterations detected by next generation sequencing are not always true biological changes but could represent sequencing errors. Even highly accurate methods can yield substantial error rates when applied to millions of nucleotides. In this study, we examined the reproducibility of nuc...

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PMID: 26136146
DOI: 10.1371/journal.pone.0119230
PMCID: PMC4489803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26136146-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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