Article
Improved Structure and Function in Autosomal Recessive Polycystic Rat Kidneys with Renal Tubular Cell Therapy.
PloS one - 1 Jan 2015
Kelly K J, Zhang Jizhong, Han Ling, Kamocka Malgorzata, Miller Caroline, Gattone Vincent H, Dominguez Jesus H
Abstract excerpt
Autosomal recessive polycystic kidney disease is a truly catastrophic monogenetic disease, causing death and end stage renal disease in neonates and children. Using PCK female rats, an orthologous model of autosomal recessive polycystic kidney disease harboring mutant Pkhd1, we tested the hypothesis that intravenous renal cell transplantation with normal Sprague Dawley male kidney cells would improve the...
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