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Article

Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells.

Stem cell research - 1 Jul 2015

Ebert Regina, Benisch Peggy, Krug Melanie, Zeck Sabine, Meißner-Weigl Jutta, Steinert Andre, Rauner Martina, Hofbauer Lorenz, Jakob Franz

Abstract excerpt

The role of serum amyloid A (SAA) proteins, which are ligands for toll-like receptors, was analyzed in human bone marrow-derived mesenchymal stem cells (hMSCs) and their osteogenic offspring with a focus on senescence, differentiation and mineralization. In vitro aged hMSC developed a senescence-associated secretory phenotype (SASP), resulting in enhanced SAA1/2, TLR2/4 and proinflammatory cytokine (IL6, IL8,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26135899
DOI: 10.1016/j.scr.2015.06.008

Genes

SAA1
TLR4
CXCL1
CXCL2
MSC
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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