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Article

Inhibitory effect of TGF-β peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts.

Pharmaceutical biology - 1 Jul 2016

Wang Xiuxia, Gao Zhen, Wu Xiaoli, Zhang Wenjie, Zhou Guangdong, Liu Wei

Abstract excerpt

CONTEXT: TGF-β plays a central role in hypertrophic scar (HS) formation and development. OBJECTIVE: This study investigated the role of a TGF-β antagonist peptide in inhibiting fibrotic behavior of human HS-derived fibroblasts (HSFs). MATERIALS AND METHODS: HSFs were seeded at a density of 3.1 × 10(4)/cm(2) and were subjected to treatment of peptide antagonist (30 μM) or TGF-β receptor inhibitor LY2109761 (10 μM)...

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Source

Identifiers

PMID: 26135051
DOI: 10.3109/13880209.2015.1059862

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CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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