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Article

Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes.

PloS one - 1 Jan 2015

Shigemizu Daichi, Aiba Takeshi, Nakagawa Hidewaki, Ozaki Kouichi, Miya Fuyuki, Satake Wataru, Toda Tatsushi, Miyamoto Yoshihiro, Fujimoto Akihiro, Suzuki Yutaka, Kubo Michiaki, Tsunoda Tatsuhiko, Shimizu Wataru, Tanaka Toshihiro

Abstract excerpt

Long QT syndrome (LQTS) is an arrhythmogenic disorder that can lead to sudden death. To date, mutations in 15 LQTS-susceptibility genes have been implicated. However, the genetic cause for approximately 20% of LQTS patients remains elusive. Here, we performed whole-exome sequencing analyses on 59 LQTS and 61 unaffected individuals in 35 families and 138 unrelated LQTS cases, after genetic screening of known LQTS...

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Identifiers

PMID: 26132555
DOI: 10.1371/journal.pone.0130329
PMCID: PMC4488844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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