Article
An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.
Circulation - 11 Feb 2020
Adler Arnon, Novelli Valeria, Amin Ahmad S, Abiusi Emanuela, Care Melanie, Nannenberg Eline A, Feilotter Harriet, Amenta Simona, Mazza Daniela, Bikker Hennie, Sturm Amy C, Garcia John, Ackerman Michael J, Hershberger Raymond E, Perez Marco V, Zareba Wojciech, Ware James S, Wilde Arthur A M, Gollob Michael H
Abstract excerpt
BACKGROUND: Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. Because of dramatic changes in our understanding of human genetic variation, reappraisal of reported genetic causes for LQTS is required. METHODS: Utilizing an evidence-based framework, 3 gene...
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