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Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

1 Jun 2015

Abstract excerpt

Immortalized cells, generated from two-dimensional cell culture techniques, are widely used in compound screening, lead optimization, and drug candidate selection. However, such cells lack many characteristics of cells in vivo. This could account for the high failure rates of lead candidates in clinical evaluation. New approaches from cell biology, materials science, and bioengineering are increasing the utility...

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PMID: 26121065
DOI: 10.1089/adt.2015.647

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