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Article

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

25 Jun 2015

Abstract excerpt

Enterovirus 71 (EV71) is the major etiological agent of hand, foot, and mouth disease (HFMD). Early studies showed that EV71-infected patients with severe complications exhibited elevated plasma levels of IL-1β, indicating that EV71 may activate inflammasomes. Our current study demonstrates that the NLRP3 inflammasome plays a protective role against EV71 infection of mice in vivo. EV71 replication in myeloid...

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PMID: 26119741
DOI: 10.1016/j.celrep.2015.05.047

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