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Article

Association of CDK4 germline and BRAF somatic mutations in a patient with multiple primary melanomas and BRAF inhibitor resistance.

Melanoma research - 1 Oct 2015

Governa Maurizio, Caprarella Evelina, Dalla Pozza Edoardo, Vigato Enrico, Maritan Monia, Caputo Glenda G, Zannoni Marina, Rosina Paolo, Elefanti Lisa, Stagni Camilla, Menin Chiara

Abstract excerpt

Many genetic alterations, including predisposing or somatic mutations, may contribute toward the development of melanoma. Although CDKN2A and CDK4 are high-penetrance genes for melanoma, MC1R is a low-penetrance gene that has been associated most consistently with the disease. Moreover, BRAF is t...

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Source

Identifiers

PMID: 26110554
DOI: 10.1097/CMR.0000000000000173

Genes

BRAF
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26110554-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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