Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir.

Abstract excerpt

The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb) and has three consensus Rb-binding motifs that might contribute to this activity. Recombinant viruses containing mutations in the Rb-binding motifs generally replicated well in human foreskin fibroblasts with only a slight delay in replication kinetics. Their susceptibility to the specific UL97 kinase inhibitor,...

Topics

• Amino Acid Motifs
• Benzimidazoles
• Cell Line
• Cells, Cultured
• Cytomegalovirus
• Enzyme Inhibitors
• Humans
• Mutation
• Phosphotransferases (Alcohol Group Acceptor)
• Retinoblastoma Protein