Article
African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans.
Investigative ophthalmology & visual science - 1 Jun 2015
Tandon Arti, Chen Ching J, Penman Alan, Hancock Heather, James Maurice, Husain Deeba, Andreoli Christopher, Li Xiaohui, Kuo Jane Z, Idowu Omolola, Riche Daniel, Papavasilieou Evangelia, Brauner Stacey, Smith Sataria O, Hoadley Suzanne, Richardson Cole, Kieser Troy, Vazquez Vanessa, Chi Cheryl, Fernandez Marlene, Harden Maegan, Cotch Mary Frances, Siscovick David, Taylor Herman A, Wilson James G, Reich David, Wong Tien Y, Klein Ronald, Klein Barbara E K, Rotter Jerome I, Patterson Nick, Sobrin Lucia
Abstract excerpt
PURPOSE: To examine the relationship between proportion of African ancestry (PAA) and proliferative diabetic retinopathy (PDR) and to identify genetic loci associated with PDR using admixture mapping in African Americans with type 2 diabetes (T2D). METHODS: Between 1993 and 2013, 1440 participants enrolled in four different studies had fundus photographs graded using the Early Treatment Diabetic Retinopathy Study...
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