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Article

Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast.

Disease models & mechanisms - 1 Aug 2015

Bi Jing, Carroll Robert T, James Michael L, Ouderkirk Jessica L, Krendel Mira, Sirotkin Vladimir

Abstract excerpt

Point mutations in the human MYO1E gene, encoding class I myosin Myo1e, are associated with focal segmental glomerulosclerosis (FSGS), a primary kidney disorder that leads to end-stage kidney disease. In this study, we used a simple model organism, fission yeast Schizosaccharomyces pombe, to test the effects of FSGS-associated mutations on myosin activity. Fission yeast has only one class I myosin, Myo1, which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26092123
DOI: 10.1242/dmm.020214
PMCID: PMC4527290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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