Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma

19 Oct 2023

Abstract excerpt

Ribonucleotide reductase (RR) is a rate-limiting enzyme that facilitates DNA replication and repair by reducing nucleotide diphosphates (NDPs) to deoxyribonucleotide diphosphates (dNDPs) and is thereby crucial for cell proliferation and cancer development. The E2F family of transcription factors includes key regulators of gene expression involved in cell cycle control. In this study, E2F8 expression was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37863324
DOI: 10.1016/j.bcp.2023.115854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinomaPMID 37863324Read ↗

Independent prognostic implications of RRM2 in lung adenocarcinomaSemantic proximity Read ↗

RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinomaSemantic proximity Read ↗

E2F8 as a Novel Therapeutic Target for Lung CancerSemantic proximity Read ↗

YTHDF1 Facilitates Lung Adenocarcinoma Progression via Promotion of EEF1G Translation in a m6A-Dependent MannerSemantic proximity Read ↗

The role of E2F2 in cancer progression and its value as a therapeutic targetSemantic proximity Read ↗

A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumorsSemantic proximity Read ↗

RDM1 plays an oncogenic role in human lung adenocarcinoma cellsSemantic proximity Read ↗

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancerSemantic proximity Read ↗

Evaluation of Clinical Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma via BioinformaticsSemantic proximity Read ↗

An Update on the Potential Roles of E2F Family Members in Colorectal CancerSemantic proximity Read ↗

Evaluation of clinical value and potential mechanism of MTFR2 in lung adenocarcinoma via bioinformaticsSemantic proximity Read ↗

FOXA1 Targets NEK2 to Mediate Cisplatin Resistance in Lung Adenocarcinoma Cells by Activating DNA Damage RepairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.