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Article

Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction.

Neuroendocrinology - 1 Jan 2016

Min Le, Nie Min, Zhang Anna, Wen Junping, Noel Sekoni D, Lee Vivian, Carroll Rona S, Kaiser Ursula B

Abstract excerpt

INTRODUCTION: Many missense variants in G protein-coupled receptors (GPCRs) involved in the neuroendocrine regulation of reproduction have been identified by phenotype-driven or large-scale exome sequencing. Computational functional prediction analysis is commonly performed to evaluate their impact on receptor function. METHODS: To assess the performance and outcome of functional prediction analyses for these...

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PMID: 26088945
DOI: 10.1159/000435884
PMCID: PMC4684493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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