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Article

Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population.

PloS one - 1 Jan 2015

Lye Munn-Sann, Visuvanathan Shaneeta, Chong Pei-Pei, Yap Yoke-Yeow, Lim Chin-Chye, Ban Eng-Zhuan

Abstract excerpt

The xeroderma pigmentosum group D (XPD) gene encodes a DNA helicase, an important component in transcription factor IIH (TFIIH) complex. XPD helicase plays a pivotal role in unwinding DNA at the damaged region during nucleotide excision repair (NER) mechanism. Dysfunctional XPD helicase protein from polymorphic diversity may contribute to increased risk of developing cancers. This study aims to determine the...

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Identifiers

PMID: 26086338
DOI: 10.1371/journal.pone.0130530
PMCID: PMC4472930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population.PMID 26086338Read ↗

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