Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC.

doi:10.1371/journal.pone.0129280

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Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC.

PloS one - 1 Jan 2015

Zhao Xiaobei, Wang Anyou, Walter Vonn, Patel Nirali M, Eberhard David A, Hayward Michele C, Salazar Ashley H, Jo Heejoon, Soloway Matthew G, Wilkerson Matthew D, Parker Joel S, Yin Xiaoying, Zhang Guosheng, Siegel Marni B, Rosson Gary B, Earp H Shelton, Sharpless Norman E, Gulley Margaret L, Weck Karen E, Hayes D Neil, Moschos Stergios J

Abstract excerpt

The recent FDA approval of the MiSeqDx platform provides a unique opportunity to develop targeted next generation sequencing (NGS) panels for human disease, including cancer. We have developed a scalable, targeted panel-based assay termed UNCseq, which involves a NGS panel of over 200 cancer-associated genes and a standardized downstream bioinformatics pipeline for detection of single nucleotide variations (SNV)...

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PMID: 26076459
DOI: 10.1371/journal.pone.0129280
PMCID: PMC4468211

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