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Article

Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells

27 May 2015

Abstract excerpt

BACKGROUND: Recently, we have reported the induction of apoptosis by 2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene (3-NC) in HepG2, T47D and HCT116 cells with low nano molar IC50 values. In this study, anti-proliferative effects of modified 4-aryle-4H-chromenes derivatives; 2-amino-4-(3-bromophenyl)-3-cyano-7-(dimethylamino)-4H-chromene (3-BC),...

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PMID: 26074734
DOI: 10.1186/s12935-015-0204-2

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