Article
Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.
Cellular & molecular immunology - 1 Nov 2016
Romanets-Korbut Olga, Kovalevska Larysa M, Seya Tsukasa, Sidorenko Svetlana P, Horvat Branka
Abstract excerpt
Measles virus (MV) is highly contagious pathogen, which causes a profound immunosuppression, resulting in high infant mortality. This virus infects dendritic cells (DCs) following the binding of MV hemagglutinin (MV-H) to CD150 receptor and alters DC functions by a mechanism that is not completely understood. We have analyzed the effect of MV-H interaction with CD150-expressing DCs on the DC signaling pathways...
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