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Article

Unravelling personalized dysfunctional gene network of complex diseases based on differential network model.

Journal of translational medicine - 13 Jun 2015

Yu Xiangtian, Zeng Tao, Wang Xiangdong, Li Guojun, Chen Luonan

Abstract excerpt

In the conventional analysis of complex diseases, the control and case samples are assumed to be of great purity. However, due to the heterogeneity of disease samples, many disease genes are even not always consistently up-/down-regulated, leading to be under-estimated. This problem will seriously influence effective personalized diagnosis or treatment. The expression variance and expression covariance can...

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Identifiers

PMID: 26070628
DOI: 10.1186/s12967-015-0546-5
PMCID: PMC4467679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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