Article
Gene polymorphisms as risk factors for predicting the cardiovascular manifestations in Marfan syndrome. Role of folic acid metabolism enzyme gene polymorphisms in Marfan syndrome.
Thrombosis and haemostasis - 1 Oct 2015
Benke Kálmán, Ágg Bence, Mátyás Gábor, Szokolai Viola, Harsányi Gergely, Szilveszter Bálint, Odler Balázs, Pólos Miklós, Maurovich-Horvat Pál, Radovits Tamás, Merkely Béla, Nagy Zsolt B, Szabolcs Zoltán
Abstract excerpt
Folic acid metabolism enzyme polymorphisms are believed to be responsible for the elevation of homocysteine (HCY) concentration in the blood plasma, correlating with the pathogenesis of aortic aneurysms and aortic dissection. We studied 71 Marfan patients divided into groups based on the severity of cardiovascular involvement: no intervention required (n=27, Group A); mild involvement requiring intervention...
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