Article
Expression profiling of white sponge nevus by RNA sequencing revealed pathological pathways.
Orphanet journal of rare diseases - 11 Jun 2015
Cai Wenping, Jiang Beizhan, Feng Tienan, Xue Jinfeng, Yang Jianhua, Chen Zhenghu, Liu Junjun, Wei Rongbin, Zhao Shouliang, Wang Xiaoping, Liu Shangfeng
Abstract excerpt
BACKGROUND: White sponge nevus (WSN) is a rare periodontal hereditary disease. To date, almost all WSN studies have focused on case reports or mutation reports. Thus, the mechanism behind WSN is still unclear. We investigated the pathogenesis of WSN using expression profiling. METHODS: Sequence analysis of samples from a WSN Chinese family revealed a mutation (332 T > C) in the KRT13 gene that resulted in the...
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