Article

Atg15 is a vacuolar phospholipase that disintegrates organelle membranes

2023-06-01

Abstract excerpt

<h4>Summary</h4> Atg15 (autophagy-related 15) is a vacuolar phospholipase essential for the degradation of cytoplasm-to-vacuole targeting (Cvt) bodies and autophagic bodies, hereinafter referred to as intravacuolar autophagic compartments (IACs), but it remains unknown if Atg15 directly disrupts IAC membranes. Here we show that the recombinant Chaetomium thermophilum Atg15 lipase domain (CtAtg15(73–475)) possess...

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Literature Corpus work: a65a7ac8-feae-5eff-b13b-4014b75f198a
DOI: 10.1101/2023.05.31.543165

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