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Article

The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer.

Clinical epigenetics - 6 Jan 2022

Loaeza-Loaeza Jaqueline, Illades-Aguiar Berenice, Del Moral-Hernández Oscar, Castro-Coronel Yaneth, Leyva-Vázquez Marco A, Dircio-Maldonado Roberto, Ortiz-Ortiz Julio, Hernández-Sotelo Daniel

Abstract excerpt

BACKGROUND: High-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its development. Abnormal DNA methylation has an important role in the origin and dissemination of cervical cancer and other human tumors. In this work, we analyzed the methylation of eight genes (AJAP1, CDH1, CDH13, MAGI2, MGMT, MYOD1, RASSF1A and SOX17) that...

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Identifiers

PMID: 34991696
DOI: 10.1186/s13148-021-01224-0
PMCID: PMC8740093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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