Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.

The Journal of biological chemistry - 6 Jan 2006

Yakubovskaya Elena, Chen Zhixin, Carrodeguas José A, Kisker Caroline, Bogenhagen Daniel F

Abstract excerpt

Mitochondrial DNA polymerase gamma (pol gamma) is responsible for replication and repair of mtDNA and is mutated in individuals with genetic disorders such as chronic external ophthalmoplegia and Alpers syndrome. pol gamma is also an adventitious target for toxic side effects of several antiviral compounds, and mutation of its proofreading exonuclease leads to accelerated aging in mouse models. We have used a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed DNA Polymerase
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase gamma

Share to DNA Repair

Share to DNA Replication

Share to Mitochondria

Share to Protein Subunits

Share to Surface Plasmon Resonance

Source

Identifiers

PMID: 16263719
DOI: 10.1074/jbc.M509730200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.PMID 16263719Read ↗

Functional analysis of mutant mitochondrial DNA polymerase proteins involved in human disease.Semantic proximity Read ↗

Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.Semantic proximity Read ↗

The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit.Semantic proximity Read ↗

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations.Semantic proximity Read ↗

Mitochondrial DNA polymerase-gamma and human disease.Semantic proximity Read ↗

DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations.Semantic proximity Read ↗

Polymerase gamma-related mitochondrial disorder.Semantic proximity Read ↗

Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations.Semantic proximity Read ↗

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.Semantic proximity Read ↗

DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.Semantic proximity Read ↗

Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders.Semantic proximity Read ↗

Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.