Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption.

BMC genetics - 10 Jun 2015

Ye Kaixiong, Cao Chang, Lin Xu, O'Brien Kimberly O, Gu Zhenglong

Abstract excerpt

BACKGROUND: HFE, a major regulator of iron (Fe) homeostasis, has been suggested to be under positive selection in both European and Asian populations. While the genetic variant under selection in Europeans (a non-synonymous mutation, C282Y) has been relatively well-studied, the adaptive variant in Asians and its functional consequences are still unknown. Identifying the adaptive HFE variants in Asians will not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferritins
Share to Heme
Share to Hemochromatosis Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepcidins

Share to Histocompatibility Antigens Class I

Share to Sex Factors

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 26054392
DOI: 10.1186/s12863-015-0223-y
PMCID: PMC4460683

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption.PMID 26054392Read ↗

A genetic association study of iron absorption in adults of East Asian or Northern European ancestry from the Iron Genes in East Asian and Northern European Adults Study (FeGenes).Semantic proximity Read ↗

Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.Semantic proximity Read ↗

Genetic adaptation to levels of dietary selenium in recent human history.Semantic proximity Read ↗

Haplotype analysis of the HFE gene among populations of Northern Eurasia, in patients with metabolic disorders or stomach cancer, and in long-lived people.Semantic proximity Read ↗

Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men.Semantic proximity Read ↗

Haemochromatosis gene mutations in a clustered Italian population: evidence of high prevalence in people of Celtic ancestry.Semantic proximity Read ↗

Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations.Semantic proximity Read ↗

Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.