Article
T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides.
Journal of the American Academy of Dermatology - 1 Aug 2015
Sufficool Kari E, Lockwood Christina M, Abel Haley J, Hagemann Ian S, Schumacher Jonathan A, Kelley Todd W, Duncavage Eric J
Abstract excerpt
BACKGROUND: T-cell receptor (TCR) clonality assessment is a principal diagnostic test in the management of mycosis fungoides (MF). However, current polymerase chain reaction-based methods may produce ambiguous results, often because of low abundance of clonal T lymphocytes, resulting in weak clonal peaks that cannot be size-resolved by contemporary capillary electrophoresis (CE). OBJECTIVE: We sought to determine...
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