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Article

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells.

Oncotarget - 28 Aug 2015

Lakshmanan Imayavaramban, Seshacharyulu Parthasarathy, Haridas Dhanya, Rachagani Satyanarayana, Gupta Suprit, Joshi Suhasini, Guda Chittibabu, Yan Ying, Jain Maneesh, Ganti Apar K, Ponnusamy Moorthy P, Batra Surinder K

Abstract excerpt

Several studies have demonstrated that MUC4 is involved in progression and metastasis of pancreatic cancer (PC). Here, we report that HER3/MUC4 interaction in HER2 low cells is critical in driving pancreatic tumorigenesis. Upon HER2 knockdown, we observed elevated expression of HER3 and MUC4 and their interactions, which was confirmed by immunoprecipitation and bioinformatics analyses. In paired human PC tissues,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26035354
DOI: 10.18632/oncotarget.3912
PMCID: PMC4673252

Genes

MUC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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