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Article

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.

Chest - 1 Jun 2015

Calfee Carolyn S, Janz David R, Bernard Gordon R, May Addison K, Kangelaris Kirsten N, Matthay Michael A, Ware Lorraine B

Abstract excerpt

BACKGROUND: ARDS is a heterogeneous syndrome that encompasses lung injury from both direct and indirect sources. Direct ARDS (pneumonia, aspiration) has been hypothesized to cause more severe lung epithelial injury than indirect ARDS (eg, nonpulmonary sepsis); however, this hypothesis has not been well studied in humans. METHODS: We measured plasma biomarkers of lung epithelial and endothelial injury and...

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Identifiers

PMID: 26033126
DOI: 10.1378/chest.14-2454
PMCID: PMC4451708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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