Article
Race Does Not Predict Melanocyte Heterogeneous Responses to Dermal Fibroblast-Derived Mediators.
PloS one - 1 Jan 2015
Sirimahachaiyakul Pornthep, Sood Ravi F, Muffley Lara A, Seaton Max, Lin Cheng-Ta, Qiao Liang, Armaly Jeffrey S, Hocking Anne M, Gibran Nicole S
Abstract excerpt
INTRODUCTION: Abnormal pigmentation following cutaneous injury causes significant patient distress and represents a barrier to recovery. Wound depth and patient characteristics influence scar pigmentation. However, we know little about the pathophysiology leading to hyperpigmentation in healed shallow wounds and hypopigmentation in deep dermal wound scars. We sought to determine whether dermal fibroblast...
Topics
- Black or African American
- Cell Proliferation
- Cells, Cultured
- Cicatrix
- Culture Media, Conditioned
- Fibroblasts
- Humans
- Hyperpigmentation
- Hypopigmentation
- Keratinocytes
- Melanins
- Melanocytes
- Polymorphism, Single Nucleotide