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Article

Is JAK2 V617F mutation more than a diagnostic index? A meta-analysis of clinical outcomes in essential thrombocythemia.

Leukemia research - 1 Jan 2009

Dahabreh Issa J, Zoi Katerina, Giannouli Stavroula, Zoi Christine, Loukopoulos Dimitrios, Voulgarelis Michael

Abstract excerpt

A systematic review and meta-analysis was carried out to compare the frequency of clinically significant outcomes between JAK2 V617F positive and wild type patients with essential thrombocythemia (ET). JAK2 V617F positivity in patients with ET was associated with a clear increase in the odds of thrombosis [OR=1.83 (95% CI, 1.32-2.53), p<0.0001], and much higher odds of transformation to polycythemia vera [OR=7.67...

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Cell Division
JAK2 gene
Hematopoietic Stem Cells
Janus Kinase 2
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycythemia Vera

Thrombocythemia, Essential

Source

Identifiers

PMID: 18632151
DOI: 10.1016/j.leukres.2008.06.006

Genes

JAK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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